Gecko possess outstanding locomotive abilities on various surfaces in different environments. Exquisite micro or nano-hierarchical structures on their toe pads, which are normally divided into hairy (setal) and smooth pads, play a critical role in adhesion and are referred to as structured adhesives. Its setae are composed of a hard material (β-keratin) with an inherent elastic modulus of 2–4 GPa. Considering the geometry of the hierarchical setal array, however, the gecko’s toe pads can rapidly form reliable contacts on surfaces with a roughness of different length scales. The proper contact between the seta and the counterpart surface generates Van der Waals forces. Millions of these contact points per toe pad acquire enough adhesion force to support the body weight of the gecko.